A PHASE 2A RANDOMIZED, DOUBLE-BLIND, DOSE-OPTIMIZING STUDY TO EVALUATE THE IMMUNOGENICITY AND SAFETY OF A BIVALENT DNA VACCINE FOR HEMORRHAGIC FEVER WITH RENAL SYNDROME DELIVERED BY INTRAMUSCULAR ELECTROPORATION

Hantaan virus (HTNV) and Puumala virus (PUUV) are pathogenic hantaviruses found in Asia and Europe, respectively.DNA vaccines targeting the envelope glycoproteins of these viruses have been constructed and found to elicit neutralizing antibodies when delivered to humans by various technologies including intramuscular electroporation.Here, we report

Variations of the elemental relative rate of Temporary Hair Color growth are modeled for parabolic, elliptic and hyperbolic domes of shoot apices by using the growth tensor in a suitable curvilinear coordinate system when the mode of area growth on the dome surface is known.Variations of growth rates within the domes are obtained in forms of comput

Snow models that solve coupled energy and mass balances require model parameters to be set, just like their conceptual CASUAL ACT counterparts.Despite the physical basis of these models, appropriate choices of the parameter values entail a rather high degree of uncertainty as some of them are not directly measurable, observations are lacking, or va

Joseph Tauber,1 James Owen,2 Marc Bloomenstein,3 John Hovanesian,4 Mark A Bullimore5 1Tauber Eye Center, Kansas City, MO 64111, USA; 2TLC Laser Eye Centers-La Jolla, La Jolla, CA 92122, USA; 3Schwartz Laser Eye Center, Scottsdale, AZ 85260, USA; 4Harvard Eye Associates, Laguna Hills, CA 92653, USA; 5University of Houston, College of Optometry, Hous